With the rise of weight loss medications like Ozempic, any time a celebrity debuts a dramatic weight loss, it’s hard for them to beat the GLP-1 allegations. Once upon a time, these drugs were mostly used to treat Type 2 diabetes, but in recent years, they’ve become a go-to for instant weight loss in Hollywood. Oprah called them “tools” for keeping people healthy, but many celebs have outright denied using them. Here are 10 stars who are the subject of Ozempic rumors.
Adele
Adele has churned out plenty of smash hits and has done so while fighting the unrealistic body-image standards that pop stars continue to face. In 2012, she said, “I don’t want to be some Skinny Minnie with my t*** out.” However, in 2020, she went viral for showcasing a 100-pound weight loss. Although she claimed that her weight loss was achieved through diet and workouts, many speculated it was actually due to semaglutide, particularly because of her hollowed cheeks.
Jonah HIll
While Jonah Hill’s earlier roles were mostly informed by his regular Joe appearance and being overweight, he gave himself a makeover when he shed a ton of weight. In his 2026 movie “Outcome,” he’s looking slimmer than ever, with one nutritionist telling Hello! Magazine that he dropped around 200 pounds. He’s faced accusations of Ozempic face more than once.
Kim and Khloe Kardashian
While she started out naturally curvy, Kim K has lost a decent amount of weight over the years. In 2022, she admitted that she achieved double-digit weight loss in just weeks to fit into a dress that Marilyn Monroe once wore. One Redditor said, “The Ozempic era definitely started with Marilyn’s dress,” and her name was connected with the drug over the years. Khloe also underwent a significant transformation, and although she hasn’t explicitly stated it, she expressed her willingness to try it when she was younger.
50 Cent
Rapper 50 Cent is known for having a bulky body type, but he lost 43 pounds in 2024, and many said it was thanks to a GLP-1. 50 Cent’s response? “Everybody talking about weight loss. I was in the gym. I was working the f*** out, man. Who says Ozempic? I was running. I was running, I was doing what I had to do. … I was 253 pounds, I came down and I’m 210 right now. Oww, so how you feel about it?”
Mindy Kaling
Once delegated to the role of adorable side character, Mindy Kaling is now a power player in Hollywood. In 2023, she lost around 40 pounds, saying she felt great, but she didn’t detail how she achieved it. She did mention that she loved running and hiking, doing up to 20 miles per week of one or the other. However, many say that to reach such results after years of battling your natural body type, Ozempic was the only way.
Jessica Simpson
This 90s and 2000s pop princess was once in the press for her catchy tunes, but once her heyday passed, she was in the tabloids for another reason—her appearance. Some of the comments were seriously cruel; despite still being gorgeous with some curves, she was judged for wearing “mom jeans” at a chili cook-off with a punny TMZ headline that read, “Jessica Simpson: This Is How She Rolls.” She spoke out about how hurtful the comments were and how they stayed with her, and years later, she’s significantly leaner. While she’s denied Ozempic, social media users speculated that she was on it and that it was getting too thin, which was the reason for her divorce.
Jesse Plemons
This actor told Entertainment Tonight that he lost 50 pounds over the course of a year and a half, and while a sleeker image was a benefit, the biggest pro was having more energy to keep up with his young kids. While he credited intermittent fasting as the backbone of his weight loss. He told the LA Times, “It’s really unfortunate that I decided to get healthy when everyone decided to take Ozempic. It doesn’t matter, everyone’s going to think I took Ozempic anyways.”
Kyle Richards
Members of the “Real Housewives” franchise are no strangers to nips, tucks, and weight loss hacks, and one of the most scrutinized is Kyle Richards of “The Real Housewives of Beverly Hills.” She’s managed to keep her physique lean over the 20 years she’s been in the spotlight, which has naturally led to GLP-1 speculation. Speaking of the rumors to Page Six, she said, “I had never heard of it. I had heard of it when they accused me, but I’d already lost weight by the time I had heard about Ozempic, so it was really frustrating to me.” Her daughter, Sophia, has admitted to taking Mounjaro and said she lost clumps of hair as a result.
